Ontology highlight
ABSTRACT:
SUBMITTER: Hill R
PROVIDER: S-EPMC5347136 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Hill Richard R Madureira Patricia A PA Ferreira Bibiana B Baptista Inês I Machado Susana S Colaço Laura L Dos Santos Marta M Liu Ningshu N Dopazo Ana A Ugurel Selma S Adrienn Angyal A Kiss-Toth Endre E Isbilen Murat M Gure Ali O AO Link Wolfgang W
Nature communications 20170309
Intrinsic and acquired resistance to chemotherapy is the fundamental reason for treatment failure for many cancer patients. The identification of molecular mechanisms involved in drug resistance or sensitization is imperative. Here we report that tribbles homologue 2 (TRIB2) ablates forkhead box O activation and disrupts the p53/MDM2 regulatory axis, conferring resistance to various chemotherapeutics. TRIB2 suppression is exerted via direct interaction with AKT a key signalling protein in cell p ...[more]