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Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation.


ABSTRACT:

Background

Interleukin-28 (IL-28B) rs12979860 C/T polymorphism is a known predictor of sustained virological response after antiviral treatment in hepatitis C. IL-28B affects the innate immune system as well as intrahepatic expression level of interferon-stimulated genes.

Objective

To investigate the effect of recipient IL-28B polymorphism on occurrence of acute rejection after liver transplantation.

Methods

140 liver allograft recipients were selected. Acute rejection episodes were recorded in 39 patients (AR group); the remaining had normal graft function (non-AR group). 70 normal subjects were also studied as the control group. The IL-28B rs12979860 was genotyped through PCR-RFLP method.

Results

No significant difference was found between AR and non-AR groups in terms of genotype and allele frequency. However, the CC genotype was significantly (p<0.001) more frequent in patients than in the control group; the C allele variants increased the risk of end-stage liver disease (OR: 2.60).

Conclusion

Liver damage in association with the carriage of IL-28B C allele is associated with a higher likelihood of developing cirrhosis.

SUBMITTER: Fereidooni H 

PROVIDER: S-EPMC5347403 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation.

Fereidooni H H   Azarpira N N   Yaghobi R R   Vahdati A A   Malek-Hoseini S A SA  

International journal of organ transplantation medicine 20170201 1


<h4>Background</h4>Interleukin-28 (IL-28B) rs12979860 C/T polymorphism is a known predictor of sustained virological response after antiviral treatment in hepatitis C. IL-28B affects the innate immune system as well as intrahepatic expression level of interferon-stimulated genes.<h4>Objective</h4>To investigate the effect of recipient IL-28B polymorphism on occurrence of acute rejection after liver transplantation.<h4>Methods</h4>140 liver allograft recipients were selected. Acute rejection epis  ...[more]

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