GARLH Family Proteins Stabilize GABA_A Receptors at Synapses.

ABSTRACT: Ionotropic neurotransmitter receptors mediate fast synaptic transmission by functioning as ligand-gated ion channels. Fast inhibitory transmission in the brain is mediated mostly by ionotropic GABA_A receptors (GABA_ARs), but their essential components for synaptic localization remain unknown. Here, we identify putative auxiliary subunits of GABA_ARs, which we term GARLHs, consisting of LH4 and LH3 proteins. LH4 forms a stable tripartite complex with GABA_ARs and neuroligin-2 in the brain. Moreover, LH4 is required for the synaptic localization of GABA_ARs and inhibitory synaptic transmission in the hippocampus. Our findings propose GARLHs as the first identified auxiliary subunits for anion channels. These findings provide new insights int

SUBMITTER: Yamasaki T 

PROVIDER: S-EPMC5347473 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature