Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC5347560 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Li Zhe Z Tseng Pang-Yen PY Tiwari Vinod V Xu Qian Q He Shao-Qiu SQ Wang Yan Y Zheng Qin Q Han Liang L Wu Zhiping Z Blobaum Anna L AL Cui Yiyuan Y Tiwari Vineeta V Sun Shuohao S Cheng Yingying Y Huang-Lionnet Julie H Y JH Geng Yixun Y Xiao Bo B Peng Junmin J Hopkins Corey C Raja Srinivasa N SN Guan Yun Y Dong Xinzhong X
Proceedings of the National Academy of Sciences of the United States of America 20170221 10
Human Mas-related G protein-coupled receptor X1 (MRGPRX1) is a promising target for pain inhibition, mainly because of its restricted expression in nociceptors within the peripheral nervous system. However, constrained by species differences across <i>Mrgprs</i>, drug candidates that activate MRGPRX1 do not activate rodent receptors, leaving no responsive animal model to test the effect on pain in vivo. Here, we generated a transgenic mouse line in which we replaced mouse <i>Mrgprs</i> with huma ...[more]