Ontology highlight
ABSTRACT:
SUBMITTER: Prevostel C
PROVIDER: S-EPMC5347687 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Prévostel Corinne C Rammah-Bouazza Cyrine C Trauchessec Hélène H Canterel-Thouennon Lucile L Busson Muriel M Ychou Marc M Blache Philippe P
Oncotarget 20161201 50
SOX9 inactivation is frequent in colorectal cancer (CRC) due to SOX9 gene mutations and/or to ectopic expression of MiniSOX9, a dominant negative inhibitor of SOX9. In the present study, we report a heterozygous L142P inactivating mutation of SOX9 in the DLD-1 CRC cell line and we demonstrate that the conditional expression of a wild type SOX9 in this cell line inhibits cell growth, clonal capacity and colonosphere formation while decreasing both the activity of the oncogenic Wnt/ß-catenin signa ...[more]