Ontology highlight
ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC5347730 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Lu Jiaxiong J Guan Shan S Zhao Yanling Y Yu Yang Y Wang Yongfeng Y Shi Yonghua Y Mao Xinfang X Yang Kristine L KL Sun Wenjing W Xu Xin X Yi Joanna S JS Yang Tianshu T Yang Jianhua J Nuchtern Jed G JG
Oncotarget 20161201 50
Neuroblastoma (NB), which accounts for about 15% of cancer-related mortality in children, is the most common childhood extracranial malignant tumor. In NB, somatic mutations of the tumor suppressor, p53, are exceedingly rare. Unlike in adult tumors, the majority of p53 downstream functions are still intact in NB cells with wild-type p53. Thus, restoring p53 function by blocking its interaction with p53 suppressors such as MDM2 is a viable therapeutic strategy for NB treatment. Herein, we show th ...[more]