Ontology highlight
ABSTRACT:
SUBMITTER: Park JS
PROVIDER: S-EPMC5347771 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Park Joon-Suk JS Lee ChuHee C Kim Hyun-Kyoung HK Kim Dayea D Son Jung Beom JB Ko Eunhwa E Cho Joong-Heui JH Kim Nam-Doo ND Nan Hong-Yan HY Kim Choong-Yong CY Yoon Sukkyoon S Lee Sun-Hwa SH Choi Hwan Geun HG
Oncotarget 20161201 50
Breast cancer is the most common malignant disease occurring in women and represents a substantial proportion of the global cancer burden. In these patients, metastasis but not the primary tumor is the main cause of breast cancer-related deaths. Here, we report the novel finding that DN10764 (AZD7762, a selective inhibitor of checkpoint kinases 1 and 2) can suppress breast cancer metastasis. In breast cancer cells, DN10764 inhibited cell proliferation and GAS6-mediated AXL signaling, consequentl ...[more]