Differential gene expression patterns between smokers and non-smokers: cause or consequence?
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ABSTRACT:
SUBMITTER: Vink JM
PROVIDER: S-EPMC5347870 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Differential gene expression patterns between smokers and non-smokers: cause or consequence?
Vink Jacqueline M JM Jansen Rick R Brooks Andy A Willemsen Gonneke G van Grootheest Gerard G de Geus Eco E Smit Jan H JH Penninx Brenda W BW Boomsma Dorret I DI
Addiction biology 20151122 2
The molecular mechanisms causing smoking-induced health decline are largely unknown. To elucidate the molecular pathways involved in cause and consequences of smoking behavior, we conducted a genome-wide gene expression study in peripheral blood samples targeting 18 238 genes. Data of 743 smokers, 1686 never smokers and 890 ex-smokers were available from two population-based cohorts from the Netherlands. In addition, data of 56 monozygotic twin pairs discordant for ever smoking were used. One hu ...[more]
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