Ontology highlight
ABSTRACT:
SUBMITTER: Gao Y
PROVIDER: S-EPMC5348319 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Gao Yanni Y Zhang Yao Y Yao Yongxiu Y Guan Xiaolu X Liu Yongzhen Y Qi Xiaole X Wang Yongqiang Y Liu Changjun C Zhang Yanping Y Gao Honglei H Nair Venugopal V Wang Xiaomei X Gao Yulong Y
Oncotarget 20161201 49
Avian leukosis virus subgroup J (ALV-J) is an oncogenic virus causing hemangiomas and myeloid tumors in chickens. Interleukin-6 (IL-6) is a multifunctional pro-inflammatory interleukin involved in many types of cancer. We previously demonstrated that IL-6 expression was induced following ALV-J infection in chickens. The aim of this study is to characterize the mechanism by which ALV-J induces IL-6 expression, and the role of IL-6 in tumor development. Our results demonstrate that ALV-J infection ...[more]