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ABSTRACT:
SUBMITTER: Ogata T
PROVIDER: S-EPMC5348924 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20080924 42
Mild palladium-catalyzed aminations of aryl tosylates and the first aminations of heteroaryl tosylates are described. In the presence of the combination of L2Pd(0) (L = P(o-tol)3) and the hindered Josiphos ligand CyPF-t-Bu, a variety of primary alkylamines and arylamines react with both aryl and heteroaryl tosylates at room temperature to form the corresponding secondary arylamines in high yields with complete selectivity for the monoarylamine. These reactions at room temperature occur in many c ...[more]