Ontology highlight
ABSTRACT:
SUBMITTER: Goncalves AP
PROVIDER: S-EPMC5349132 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Gonçalves A P AP Monteiro João J Lucchi Chiara C Kowbel David J DJ Cordeiro J M JM Correia-de-Sá Paulo P Rigden Daniel J DJ Glass N L NL Videira Arnaldo A
Microbial cell (Graz, Austria) 20140809 9
Alterations in the intracellular levels of calcium are a common response to cell death stimuli in animals and fungi and, particularly, in the <i>Neurospora crassa</i> response to staurosporine. We highlight the importance of the extracellular availability of Ca<sup>2+</sup> for this response. Limitation of the ion in the culture medium further sensitizes cells to the drug and results in increased accumulation of reactive oxygen species (ROS). Conversely, an approximately 30-fold excess of extern ...[more]