Ontology highlight
ABSTRACT:
SUBMITTER: Beenukumar RR
PROVIDER: S-EPMC5349141 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Beenukumar R R RR Gödderz Daniela D Palanimurugan R R Dohmen R J RJ
Microbial cell (Graz, Austria) 20150520 6
Ornithine decarboxylase (ODC), a ubiquitin-independent substrate of the proteasome, is a homodimeric protein with a rate-limiting function in polyamine biosynthesis. Polyamines regulate ODC levels by a feedback mechanism mediated by ODC antizyme (OAZ). Higher cellular polyamine levels trigger the synthesis of OAZ and also inhibit its ubiquitin-dependent proteasomal degradation. OAZ binds ODC monomers and targets them to the proteasome. Here, we report that polyamines, aside from their role in th ...[more]