Ontology highlight
ABSTRACT:
SUBMITTER: Guerreiro Castro S
PROVIDER: S-EPMC5349337 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Guerreiro Castro Sara S Isenberg David A DA
Therapeutic advances in musculoskeletal disease 20170301 3
Systemic lupus erythematosus (SLE) is a complex autoimmune rheumatic disease with multiple presentations, whose management presents many challenges. Many disease modifying or immunosuppressive drugs have been used with limited success, especially in patients with more severe disease activity. Belimumab is the first drug to be approved specifically for the treatment of SLE in more than 50 years. By blocking the B-cell activating factor, it interferes in B-cell differentiation and survival. Here w ...[more]