Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data.

ABSTRACT: The use of animal models of arthritis is a key component in the evaluation of therapeutic strategies against the human disease rheumatoid arthritis (RA). Here we present quantitative measurements of bone degradation characterised by the cortical bone profile using glucose-6-phosphate isomerase (G6PI) induced arthritis. We applied micro-computed tomography (μCT) during three arthritis experiments and one control experiment to image the metatarsals of the hind paws and to investigate the effect of experimental arthritis on their cortical bone profile. For measurements of the cortical profile we automatically identified slices that are orthogonal to individual metatarsals, thereby making the measurements independent of animal placement in the scanner. We measured the average cortical thicknes

SUBMITTER: Svensson CM 

PROVIDER: S-EPMC5349516 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature