Ontology highlight
ABSTRACT:
SUBMITTER: Jansen HJ
PROVIDER: S-EPMC5349540 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Jansen Hailey J HJ Moghtadaei Motahareh M Mackasey Martin M Rafferty Sara A SA Bogachev Oleg O Sapp John L JL Howlett Susan E SE Rose Robert A RA
Scientific reports 20170314
Atrial fibrillation (AF) is prevalent in aging populations; however not all individuals age at the same rate. Instead, individuals of the same chronological age can vary in health status from fit to frail. Our objective was to determine the impacts of age and frailty on atrial function and arrhythmogenesis in mice using a frailty index (FI). Aged mice were more frail and demonstrated longer lasting AF compared to young mice. Consistent with this, aged mice showed longer P wave duration and PR in ...[more]