Ontology highlight
ABSTRACT:
SUBMITTER: Busnelli M
PROVIDER: S-EPMC5349609 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Busnelli Marco M Manzini Stefano S Hilvo Mika M Parolini Cinzia C Ganzetti Giulia S GS Dellera Federica F Ekroos Kim K Jänis Minna M Escalante-Alcalde Diana D Sirtori Cesare R CR Laaksonen Reijo R Chiesa Giulia G
Scientific reports 20170314
The PLPP3 gene encodes for a ubiquitous enzyme that dephosphorylates several lipid substrates. Genome-wide association studies identified PLPP3 as a gene that plays a role in coronary artery disease susceptibility. The aim of the study was to investigate the effect of Plpp3 deletion on atherosclerosis development in mice. Because the constitutive deletion of Plpp3 in mice is lethal, conditional Plpp3 hepatocyte-specific null mice were generated by crossing floxed Plpp3 mice with animals expressi ...[more]