New differentially expressed genes and differential DNA methylation underlying refractory epilepsy.
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ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC5349997 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
New differentially expressed genes and differential DNA methylation underlying refractory epilepsy.
Liu Xi X Ou Shu S Xu Tao T Liu Shiyong S Yuan Jinxian J Huang Hao H Qin Lu L Yang Hui H Chen Lifen L Tan Xinjie X Chen Yangmei Y
Oncotarget 20161201 52
Epigenetics underlying refractory epilepsy is poorly understood, especially in patients without distinctive genetic alterations. DNA methylation may affect gene expression in epilepsy without affecting DNA sequences. Herein, we analyzed genome-wide DNA methylation and gene expression in brain tissues of 10 patients with refractory epilepsy using methylated DNA immunoprecipitation linked with sequencing and mRNA Sequencing. Diverse distribution of differentially methylated genes was found in X ch ...[more]
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