Unknown

Dataset Information

0

Early response to neoadjuvant chemotherapy can help predict long-term survival in patients with cervical cancer.


ABSTRACT: It is still controversial whether cervical cancer patients with clinical responses after neoadjuvant chemotherapy (NACT) have a better long-term survival or not. This study was designed to investigate the effect of the clinical response on the disease-free survival (DFS) of cervical cancer patients undergoing NACT. A total of 853 patients from a retrospective study were used to evaluate whether the clinical response was an indicator for the long-term response, and 493 patients from a prospective cohort study were used for further evaluation. The survival difference was detected by log-rank test, univariate and multivariate Cox regression and a pooled analysis. The log-rank test revealed that compared with non-responders, the DFS of responders was significantly higher in the retrospective data (P = 0.007). Univariate Cox regression showed that the clinical response was an indicator of long-term survival in the retrospective study (HR 1.83, 95% CI 1.18-2.85, P = 0.007). In a multivariate Cox model, the clinical response was still retained as an independent significant prognostic factor in the retrospective study (HR 1.59, 95% CI 1.01-2.50, P = 0.046). The result was also validated in the prospective data with similar results. These findings implied that the clinical response can be regarded as an independent predictor of DFS.

SUBMITTER: Li X 

PROVIDER: S-EPMC5350004 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications


It is still controversial whether cervical cancer patients with clinical responses after neoadjuvant chemotherapy (NACT) have a better long-term survival or not. This study was designed to investigate the effect of the clinical response on the disease-free survival (DFS) of cervical cancer patients undergoing NACT. A total of 853 patients from a retrospective study were used to evaluate whether the clinical response was an indicator for the long-term response, and 493 patients from a prospective  ...[more]

Similar Datasets

| S-EPMC5784110 | biostudies-literature
| S-EPMC5601760 | biostudies-literature
| S-EPMC4915007 | biostudies-literature
| S-EPMC6694396 | biostudies-literature
| S-EPMC6567713 | biostudies-literature
| S-EPMC5423520 | biostudies-literature
| S-EPMC5493088 | biostudies-literature
| S-EPMC10587964 | biostudies-literature
| S-EPMC7249312 | biostudies-literature
| S-EPMC9092215 | biostudies-literature