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Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students.

ABSTRACT: Background: Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. Examination of the effects of individual variants as well as aggregate genetic variation can clarify mechanisms underlying risk. Methods: We conducted genome-wide association studies (GWAS) in an ethnically diverse sample of college students for three quantitative outcomes including typical monthly alcohol consumption, alcohol problems, and maximum number of drinks in 24 h. Heritability based on common genetic variants (h2SNP) was assessed. We also evaluated whether risk variants in aggregate were associated with alcohol use outcomes in an independent sample of young adults. Results: Two genome-wide significant markers were observed: rs11201929 in GRID1 for maximum drinks in 24 h, with supportive evidence across all ancestry groups; and rs73317305 in SAMD12 (alcohol problems), tested only in the African ancestry group. The h2SNP estimate was 0.19 (SE = 0.11) for consumption, and was non-significant for other outcomes. Genome-wide polygenic scores were significantly associated with alcohol outcomes in an independent sample. Conclusions: These results robustly identify genetic risk for alcohol use outcomes at the variant level and in aggregate. We confirm prior evidence that genetic variation in GRID1 impacts alcohol use, and identify novel loci of interest for multiple alcohol outcomes in emerging adults. These findings indicate that genetic variation influencing normative and problematic alcohol use is, to some extent, convergent across ancestry groups. Studying college populations represents a promising avenue by which to obtain large, diverse samples for gene identification.

SUBMITTER: Webb BT

PROVIDER: S-EPMC5350109 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students.

Webb Bradley T BT Edwards Alexis C AC Wolen Aaron R AR Salvatore Jessica E JE Aliev Fazil F Riley Brien P BP Sun Cuie C Williamson Vernell S VS Kitchens James N JN Pedersen Kimberly K Adkins Amy A Cooke Megan E ME Savage Jeanne E JE Neale Zoe Z Cho Seung B SB Dick Danielle M DM Kendler Kenneth S KS

Frontiers in genetics 20170315

<b>Background:</b> Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. Examination of the effects of individual variants as well as aggregate genetic variation can clarify mechanisms underlying risk. <b>Methods:</b> We conducted genome-wide association studies (GWAS) in an ethnically diverse sample of college students for three quantitative outcomes including typical monthly alcohol consumption, alcohol problems, and maximum n ...[more]

PMID: 28360924

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Project description:AimsProblematic social media use is increasing in China and could be a risk factor for depression. We investigated cross-sectional associations between problematic social media use and depressive outcomes among Chinese college students with potential mediation by perceived social support, social media violence, and loneliness. Thereafter, we evaluated the effectiveness of a one-month group counseling intervention in reducing depressive symptoms related to social media addiction.MethodsDepressive symptoms, social media addiction, perceived social support, social media violence, and loneliness were self-reported among 21,000 college students in Shaanxi province, China. A randomized controlled trial was designed based on the results of the observational study and Satir Transformational Systemic Therapy (STST) among 60 college students assigned to intervention (N = 30) or control/no treatment (N = 30). Self-administered surveys were completed at baseline (T1), at the end of the 1-month intervention (T2), and at 2-month follow-up post-intervention (T3).ResultsAfter controlling for relevant covariates, more problematic social media use was associated with more depressive symptoms (β = 0.18, p < 0.001) and depression (OR = 1.08, 95% CI: 1.075, 1.092). Multiple mediation analyses found that perceived social support, social media violence, and loneliness significantly mediated associations between problematic social media use and depressive symptoms (model fit: RMSEA = 0.065, GFI = 0.984, CFI = 0.982). Bootstrapping revealed significant indirect effects of problematic social media use on depressive symptoms through the mediators named above (0.143, 95% CI: 0.133, 0.156). The subsequently informed intervention significantly reduced depressive symptoms at T2 (mean difference: -12.70, 95% CI: -16.64, -8.76, p < 0.001) and at T3 (mean difference: -8.70, 95% CI: -12.60, -4.80, p < 0.001), as well as levels of social media addiction, perceived social support, social media violence, and loneliness.ConclusionsProblematic social media use is a risk factor for depressive outcomes among Chinese college students, and perceived social support, social media violence, and loneliness mediate this association. STST-based group counseling may reduce depressive symptoms related to high social media usage in this population.

Dataset Information

Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students.

Publications

Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students.

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