Ontology highlight
ABSTRACT:
SUBMITTER: Saunders CA
PROVIDER: S-EPMC5350507 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Saunders Cosmo A CA Harris Nathan J NJ Willey Patrick T PT Woolums Brian M BM Wang Yuexia Y McQuown Alex J AJ Schoenhofen Amy A Worman Howard J HJ Dauer William T WT Gundersen Gregg G GG Luxton G W Gant GW
The Journal of cell biology 20170227 3
The nucleus is positioned toward the rear of most migratory cells. In fibroblasts and myoblasts polarizing for migration, retrograde actin flow moves the nucleus rearward, resulting in the orientation of the centrosome in the direction of migration. In this study, we report that the nuclear envelope-localized AAA+ (ATPase associated with various cellular activities) torsinA (TA) and its activator, the inner nuclear membrane protein lamina-associated polypeptide 1 (LAP1), are required for rearwar ...[more]