Ontology highlight
ABSTRACT:
SUBMITTER: Nagalla S
PROVIDER: S-EPMC5351332 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Nagalla S S Thomson L L Oppong Y Y Bachman B B Chervoneva I I Kraft W K WK
Clinical and translational science 20160512 3
It was hypothesized that the four-factor prothrombin complex concentrate (4F-PCC) Kcentra 25 unit/kg would reverse impairment of thrombin generation in healthy volunteers dosed with apixaban to steady state. In this randomized, two-period crossover, assessor-blinded trial, 12 healthy subjects received 5 mg apixaban every 12 h. Three h after the fifth dose, four-factor prothrombin complex concentrate (4F-PCC) 25 unit/kg or saline were infused. Serial blood samples were assessed for thrombin gener ...[more]