Ontology highlight
ABSTRACT:
SUBMITTER: Timmis J
PROVIDER: S-EPMC5351409 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Timmis J J Alden K K Andrews P P Clark E E Nellis A A Naylor B B Coles M M Kaye P P
CPT: pharmacometrics & systems pharmacology 20170209 3
This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigor and transparency in development and application of models for therapeutic discovery and design of intervention strategies. Structured arguments over a model's development, underpinning biological knowledge, and analyses of model behaviors are constructed to determine the confidence that a model is fit for the purpose f ...[more]