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Building confidence in quantitative systems pharmacology models: An engineer's guide to exploring the rationale in model design and development.

ABSTRACT: This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigor and transparency in development and application of models for therapeutic discovery and design of intervention strategies. Structured arguments over a model's development, underpinning biological knowledge, and analyses of model behaviors are constructed to determine the confidence that a model is fit for the purpose for which it will be applied.

SUBMITTER: Timmis J

PROVIDER: S-EPMC5351409 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Building confidence in quantitative systems pharmacology models: An engineer's guide to exploring the rationale in model design and development.

Timmis J J Alden K K Andrews P P Clark E E Nellis A A Naylor B B Coles M M Kaye P P

CPT: pharmacometrics & systems pharmacology 20170209 3

This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigor and transparency in development and application of models for therapeutic discovery and design of intervention strategies. Structured arguments over a model's development, underpinning biological knowledge, and analyses of model behaviors are constructed to determine the confidence that a model is fit for the purpose f ...[more]

PMID: 27863172

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