Mathematical modeling of the effects of CK2.3 on mineralization in osteoporotic bone.
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ABSTRACT:
SUBMITTER: Lisberg A
PROVIDER: S-EPMC5351412 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Mathematical modeling of the effects of CK2.3 on mineralization in osteoporotic bone.
Lisberg A A Ellis R R Nicholson K K Moku P P Swarup A A Dhurjati P P Nohe A A
CPT: pharmacometrics & systems pharmacology 20170209 3
Osteoporosis is caused by decreased bone mineral density (BMD) and new treatments for this disease are desperately needed. Bone morphogenetic protein 2 (BMP2) is crucial for bone formation. The mimetic peptide CK2.3 acts downstream of BMP2 and increases BMD when injected systemically into the tail vein of mice. However, the most effective dosage needed to induce BMD in humans is unknown. We developed a mathematical model for CK2.3-dependent bone mineralization. We used a physiologically based ph ...[more]
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