Ontology highlight
ABSTRACT:
SUBMITTER: Sha J
PROVIDER: S-EPMC5351617 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Sha Jianjun J Xue Wei W Dong Baijun B Pan Jiahua J Wu Xiaorong X Li Dong D Liu Dongming D Huang Yiran Y
Oncotarget 20170101 4
Castration-resistant prostate cancer (CRPC) is an advanced form of prostate cancer. Despite some progresses have been made, the mechanism of CRPC development is still largely unknown, including the genes involved in its development have not been well defined. Here, we identifiedPRKAR2B to be a gene over-expressingin castration-resistant prostate cancer by analyzing the different online databases. Followed functional validation experiments showed that PRKAR2B promoted CRPC cell proliferation and ...[more]