Ontology highlight
ABSTRACT:
SUBMITTER: Lee SH
PROVIDER: S-EPMC5351654 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Lee Sung Hak SH Jung Seung Hyun SH Kim Tae-Min TM Rhee Je-Keun JK Park Hyeon-Chun HC Kim Min Sung MS Kim Sung Soo SS An Chang Hyeok CH Lee Sug Hyung SH Chung Yeun-Jun YJ
Oncotarget 20170101 4
Although gene-to-gene analyses identified genetic alterations such as APC, KRAS and TP53 mutations in colon adenomas, it is largely unknown whether there are any others in them. Mutational profiling of high-grade colon adenoma (HGCA) that just precedes colon carcinoma might identify not only novel adenoma-specific genes but also critical genes for its progression to carcinoma. For this, we performed whole-exome sequencing (WES) of 12 HGCAs and identified 11 non-hypermutated and one hypermutated ...[more]