Ontology highlight
ABSTRACT:
SUBMITTER: Mikiewicz D
PROVIDER: S-EPMC5351984 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Mikiewicz Diana D Bierczyńska-Krzysik Anna A Sobolewska Agnieszka A Stadnik Dorota D Bogiel Monika M Pawłowska Monika M Wójtowicz-Krawiec Anna A Baran Piotr A PA Łukasiewicz Natalia N Romanik-Chruścielewska Agnieszka A Sokołowska Iwona I Stadnik Jacek J Borowicz Piotr P Płucienniczak Grażyna G Płucienniczak Andrzej A
PloS one 20170315 3
The discovery of insulin led to a revolution in diabetes management. Since then, many improvements have been introduced to insulin preparations. The availability of molecular genetic techniques has enabled the creation of insulin analogs by changing the structure of the native protein in order to improve the therapeutic properties. A new expression vector pIBAINS for production of four recombinant human insulin (INS) analogs (GKR, GEKR, AKR, SR) was constructed and overexpressed in the new E. co ...[more]