DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival.
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ABSTRACT:
SUBMITTER: Fleischer T
PROVIDER: S-EPMC5352035 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival.
Fleischer Thomas T Klajic Jovana J Aure Miriam Ragle MR Louhimo Riku R Pladsen Arne V AV Ottestad Lars L Touleimat Nizar N Laakso Marko M Halvorsen Ann Rita AR Grenaker Alnæs Grethe I GI Riis Margit L H ML Helland Åslaug Å Hautaniemi Sampsa S Lønning Per Eystein PE Naume Bjørn B Børresen-Dale Anne-Lise AL Tost Jörg J Kristensen Vessela N VN
Oncotarget 20170101 1
Breast cancer patients with Luminal A disease generally have a good prognosis, but among this patient group are patients with good prognosis that are currently overtreated with adjuvant chemotherapy, and also patients that have a bad prognosis and should be given more aggressive treatment. There is no available method for subclassification of this patient group. Here we present a DNA methylation signature (SAM40) that segregates Luminal A patients based on prognosis, and identify one good progno ...[more]
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