Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC5352051 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Chen Yunyu Y Zhang Jing J Li Dongsheng D Jiang Jiandong J Wang Yanchang Y Si Shuyi S
Oncotarget 20170101 1
Polo-like kinase 1 (Plk1) is a promising target for cancer therapy due to its essential role in cell division. In addition to a highly conserved kinase domain, Plk1 also contains a Polo-Box domain (PBD), which is essential for Plk1's subcellular localization and mitotic functions. We adopted a fluorescence polarization assay and identified a new Plk1 PBD inhibitor T521 from a small-molecule compound library. T521 specifically inhibits the PBD of Plk1, but not those of Plk2-3. T521 exhibits coval ...[more]