Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway.
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ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5352075 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway.
Zhang Xiaojian X Liu Kun K Zhang Tao T Wang Zhenlei Z Qin Xuan X Jing Xiaoqian X Wu Haoxuan H Ji Xiaopin X He Yonggang Y Zhao Ren R
Oncotarget 20170101 1
Cortactin (CTTN) is overexpressed in various tumors, including head and neck squamous cell carcinoma and colorectal cancer (CRC), and can serve as a biomarker of cancer metastasis. We observed that CTTN promotes cancer cell proliferation in vitro and increases CRC tumor xenograft growth in vivo. CTTN expression increases EGFR protein levels and enhances the activation of the MAPK signaling pathway. CTTN expression also inhibits the ubiquitin-mediated degradation of EGFR by suppressing the coupli ...[more]
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