Dataset Information

High lncRNA H19 expression as prognostic indicator: data mining in female cancers and polling analysis in non-female cancers.

ABSTRACT: Upregulation of lncRNA H19 expression is associated with an unfavorable prognosis in some cancers. However, the prognostic value of H19 in female-specific cancers has remained uncharacterized. In this study, the prognostic power of high H19 expression in female cancer patients from the TCGA datasets was analyzed using Kaplan-Meier survival curves and Cox's proportional hazard modeling. In addition, in a meta-analysis of non-female cancer patients from TCGA datasets and 12 independent studies, hazard ratios (HRs) with 95% confidence interval (CI) for overall survival (OS) and disease-free survival (DFS)/relapse-free survival (RFS)/metastasis-free survival (MFS)/progression-free survival (PFS) were pooled to assess the prognostic value of high H19 expression. Kaplan-Meier analysis revealed that patients with uterine corpus cancer and higher H19 expression had a shorter OS (HR=2.710, p<0.05), while females with cervical cancer and increased H19 expression had a shorter RFS (HR=2.261, p<0.05). Multivariate Cox regression analysis showed that high H19 expression could independently predict a poorer prognosis in cervical cancer patients (HR=4.099, p<0.05). In the meta-analysis, patients with high H19 expression showed a poorer outcome in non-female cancer (p<0.05). These results suggest that high lncRNA H19 expression is predictive of an unfavorable prognosis in two female cancers (uterine corpus endometrioid cancer and cervical cancer) as well as in non-female cancer patients.

SUBMITTER: Peng L

PROVIDER: S-EPMC5352086 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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High lncRNA H19 expression as prognostic indicator: data mining in female cancers and polling analysis in non-female cancers.

Peng Li L Yuan Xiao-Qing XQ Liu Zhao-Yang ZY Li Wen-Ling WL Zhang Chao-Yang CY Zhang Ya-Qin YQ Pan Xi X Chen Jun J Li Yue-Hui YH Li Guan-Cheng GC

Oncotarget 20170101 1

Upregulation of lncRNA H19 expression is associated with an unfavorable prognosis in some cancers. However, the prognostic value of H19 in female-specific cancers has remained uncharacterized. In this study, the prognostic power of high H19 expression in female cancer patients from the TCGA datasets was analyzed using Kaplan-Meier survival curves and Cox's proportional hazard modeling. In addition, in a meta-analysis of non-female cancer patients from TCGA datasets and 12 independent studies, ha ...[more]

PMID: 27926484

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Dataset Information

High lncRNA H19 expression as prognostic indicator: data mining in female cancers and polling analysis in non-female cancers.

Publications

High lncRNA H19 expression as prognostic indicator: data mining in female cancers and polling analysis in non-female cancers.

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