Ontology highlight
ABSTRACT:
SUBMITTER: Garg M
PROVIDER: S-EPMC5352339 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Garg Manoj M Kanojia Deepika D Mayakonda Anand A Said Jonathan W JW Doan Ngan B NB Chien Wenwen W Ganesan Trivadi S TS Chuang Linda Shyue Huey LS Venkatachalam Nachiyappan N Baloglu Erkan E Shacham Sharon S Kauffman Michael M Koeffler H Phillip HP
Oncotarget 20170101 5
Exportin-1 mediates nuclear export of multiple tumor suppressor and growth regulatory proteins. Aberrant expression of exportin-1 is noted in human malignancies, resulting in cytoplasmic mislocalization of its target proteins. We investigated the efficacy of selinexor against liposarcoma cells both in vitro and in vivo. Exportin-1 was highly expressed in liposarcoma samples and cell lines as determined by immunohistochemistry, western blot, and immunofluorescence assay. Knockdown of endogenous e ...[more]