Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC5352369 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Oncotarget 20170101 5
Alzheimer's disease (AD) is the most common age-related dementia characterized by progressive neuronal loss. However, the molecular mechanisms for the neuronal loss is still debated. Here, we used induced pluripotent stem cells (iPSCs) derived from somatic cells of familial AD patients carrying PSEN1 mutations to study the early pathogenic event of AD. We found that premature neuronal differentiation with decreased proliferation and increased apoptosis occured in AD-iPSC-derived neural progenito ...[more]