Ontology highlight
ABSTRACT:
SUBMITTER: Tasian SK
PROVIDER: S-EPMC5352516 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Tasian Sarah K SK Hunger Stephen P SP
British journal of haematology 20161216 6
Major advances in genetic and epigenetic profiling of acute lymphoblastic leukaemia (ALL) have enhanced the understanding of key biological subsets of de novo and relapsed ALL, which has led to improved risk stratification of patients. These achievements have further defined critical leukaemia-associated pathways and somatic alterations that may be preferentially sensitive to treatment with kinase inhibitors, epigenetic therapy or other novel agents. Therapeutic success in childhood ALL currentl ...[more]