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Validation of the prognostic value of MMP-7 in idiopathic pulmonary fibrosis.


ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis and variable clinical course. Although matrix metalloproteinase-7 (MMP-7) is emerging as an important IPF biomarker, reproducibility across studies is unclear. We aimed to determine whether a previously reported prognostic threshold for MMP-7 was predictive of mortality in an independent cohort of IPF patients.MMP-7 concentrations obtained from heparinized plasma samples were determined by ELISA in 97 patients with IPF and 41 healthy controls. The association of the previously published heparin plasma MMP-7 threshold of 12.1?ng/mL with all-cause mortality or transplant-free survival (TFS) was determined, either as an independent biomarker or as part of the modified personal clinical and molecular mortality index (m-PCMI).MMP-7 plasma concentrations were significantly higher in IPF patients compared to healthy controls (14.40?±?6.55?ng/mL vs 6.03?±?2.51?ng/mL, P?

SUBMITTER: Tzouvelekis A 

PROVIDER: S-EPMC5352520 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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<h4>Background and objective</h4>Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis and variable clinical course. Although matrix metalloproteinase-7 (MMP-7) is emerging as an important IPF biomarker, reproducibility across studies is unclear. We aimed to determine whether a previously reported prognostic threshold for MMP-7 was predictive of mortality in an independent cohort of IPF patients.<h4>Methods</h4>MMP-7 concentrations obtained from heparinized plasma samp  ...[more]

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