Ontology highlight
ABSTRACT:
SUBMITTER: Sharma U
PROVIDER: S-EPMC5353611 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nature communications 20170310
Fibrillar collagen molecules are synthesized as precursors, procollagens, with large propeptide extensions. While a homotrimeric form (three α1 chains) has been reported in embryonic tissues as well as in diseases (cancer, fibrosis, genetic disorders), collagen type I usually occurs as a heterotrimer (two α1 chains and one α2 chain). Inside the cell, the role of the C-terminal propeptides is to gather together the correct combination of three α chains during molecular assembly, but how this occu ...[more]