Effects of Gliadin consumption on the Intestinal Microbiota and Metabolic Homeostasis in Mice Fed a High-fat Diet.
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ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC5353615 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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Effects of Gliadin consumption on the Intestinal Microbiota and Metabolic Homeostasis in Mice Fed a High-fat Diet.
Zhang Li L Andersen Daniel D Roager Henrik Munch HM Bahl Martin Iain MI Hansen Camilla Hartmann Friis CH Danneskiold-Samsøe Niels Banhos NB Kristiansen Karsten K Radulescu Ilinca Daria ID Sina Christian C Frandsen Henrik Lauritz HL Hansen Axel Kornerup AK Brix Susanne S Hellgren Lars I LI Licht Tine Rask TR
Scientific reports 20170316
Dietary gluten causes severe disorders like celiac disease in gluten-intolerant humans. However, currently understanding of its impact in tolerant individuals is limited. Our objective was to test whether gliadin, one of the detrimental parts of gluten, would impact the metabolic effects of an obesogenic diet. Mice were fed either a defined high-fat diet (HFD) containing 4% gliadin (n = 20), or a gliadin-free, isocaloric HFD (n = 20) for 23 weeks. Combined analysis of several parameters includin ...[more]
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