Ontology highlight
ABSTRACT:
SUBMITTER: Yan M
PROVIDER: S-EPMC535382 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Yan Ming M Burel Sebastien A SA Peterson Luke F LF Kanbe Eiki E Iwasaki Hiromi H Boyapati Anita A Hines Robert R Akashi Koichi K Zhang Dong-Er DE
Proceedings of the National Academy of Sciences of the United States of America 20041129 49
Normal blood-cell differentiation is controlled by regulated gene expression and signal transduction. Transcription deregulation due to chromosomal translocation is a common theme in hematopoietic neoplasms. AML1-ETO, which is a fusion protein generated by the 8;21 translocation that is commonly associated with the development of acute myeloid leukemia, fuses the AML1 runx family DNA-binding transcription factor to the ETO corepressor that associates with histone deacetylase complexes. Analyses ...[more]