Ontology highlight
ABSTRACT:
SUBMITTER: Howitt BE
PROVIDER: S-EPMC5353914 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Howitt Brooke E BE Strickland Kyle C KC Sholl Lynette M LM Rodig Scott S Ritterhouse Lauren L LL Chowdhury Dipanjan D D'Andrea Alan D AD Matulonis Ursula A UA Konstantinopoulos Panagiotis A PA
Oncoimmunology 20170106 2
Clear cell ovarian carcinoma (CCOC) represents a distinct histologic subtype of ovarian cancer associated with significantly worse prognosis across all stages and no effective therapeutic options. Here, we report a rare but clinically important cohort of CCOCs with microsatellite instability (MSI) (MSI-CCOCs), which are highly immunogenic and may thus be very responsive to immune checkpoint blockade. CCOCs with MSI exhibit a significantly higher number of CD8<sup>+</sup> TILs, higher CD8<sup>+</ ...[more]