Ontology highlight
ABSTRACT:
SUBMITTER: Tang LY
PROVIDER: S-EPMC5354477 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Tang Liu-Ya LY Heller Mary M Meng Zhaojing Z Yu Li-Rong LR Tang Yi Y Zhou Ming M Zhang Ying E YE
The Journal of biological chemistry 20170131 10
Transforming growth factor-β (TGF-β) signals through both SMAD and non-SMAD pathways to elicit a wide array of biological effects. Existing data have shown the association and coordination between STATs and SMADs in mediating TGF-β functions in hepatic cells, but it is not clear how STATs are activated under these circumstances. Here, we report that JAK1 is a constitutive TGFβRI binding protein and is absolutely required for phosphorylation of STATs in a SMAD-independent manner within minutes of ...[more]