Ontology highlight
ABSTRACT:
SUBMITTER: Lord MS
PROVIDER: S-EPMC5354495 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lord Megan S MS Cheng Bill B Farrugia Brooke L BL McCarthy Simon S Whitelock John M JM
The Journal of biological chemistry 20170123 10
Platelet factor 4 (PF4) is produced by platelets with roles in both inflammation and wound healing. PF4 is stored in platelet α-granules bound to the glycosaminoglycan (GAG) chains of serglycin. This study revealed that platelet serglycin is decorated with chondroitin/dermatan sulfate and that PF4 binds to these GAG chains. Additionally, PF4 had a higher affinity for endothelial-derived perlecan heparan sulfate chains than serglycin GAG chains. The binding of PF4 to perlecan was found to inhibit ...[more]