Ontology highlight
ABSTRACT:
SUBMITTER: Birey F
PROVIDER: S-EPMC5354631 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Birey Fikri F Kloc Michelle M Chavali Manideep M Hussein Israa I Wilson Michael M Christoffel Daniel J DJ Chen Tony T Frohman Michael A MA Robinson John K JK Russo Scott J SJ Maffei Arianna A Aguirre Adan A
Neuron 20151120 5
NG2-expressing glia (NG2 glia) are a uniformly distributed and mitotically active pool of cells in the central nervous system (CNS). In addition to serving as progenitors of myelinating oligodendrocytes, NG2 glia might also fulfill physiological roles in CNS homeostasis, although the mechanistic nature of such roles remains unclear. Here, we report that ablation of NG2 glia in the prefrontal cortex (PFC) of the adult brain causes deficits in excitatory glutamatergic neurotransmission and astrocy ...[more]