Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC5354642 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Chen Shaodan S Li Xiangmin X Yong Tianqiao T Wang Zhanggen Z Su Jiyan J Jiao Chunwei C Xie Yizhen Y Yang Burton B BB
Oncotarget 20170201 6
We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect against the human breast carcinoma cell line MDA-MB-231 and hepatocellular carcinoma cell line HepG2. Corresponding three-dimensional quantitative structure-activity relationship (3D-QSAR) models wer ...[more]