Ontology highlight
ABSTRACT:
SUBMITTER: Villoutreix BO
PROVIDER: S-EPMC5354670 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Oncotarget 20170201 6
A structure-based virtual screening of over 400,000 small molecules against the constitutive proteasome activity followed by in vitro assays led to the discovery of a family of proteasome inhibitors with a sulfonyl piperazine scaffold. Some members of this family of small non-peptidic inhibitors were found to act selectively on the β2 trypsin-like catalytic site with a preference for the immunoproteasome β2i over the constitutive proteasome β2c, while some act on the β5 site and post-acid site β ...[more]