Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC5354731 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Li Xiangyun X Li Mei M Ruan Hang H Qiu Wei W Xu Xiang X Zhang Lin L Yu Jian J
Oncotarget 20170201 6
Colorectal cancers with mutant RAS/RAF are therapy refractory. Deregulated mRNA translation has become an emerging target in cancer treatment. We recently reported that mTOR inhibitors induce apoptosis via ER stress and the extrinsic pathway upon acute inhibition of the eIF4F complex in colon cancer cells and xenografts, while mutant BRAF600E leads to therapeutic resistance via ERK-mediated Mcl-1 stabilization. In this study, we demonstrated that several other translation inhibitors also activat ...[more]