Ontology highlight
ABSTRACT:
SUBMITTER: Xia B
PROVIDER: S-EPMC5354771 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Xia Bingshu B Shan Ming M Wang Ji J Zhong Zhenbin Z Geng Jingshu J He Xiaohui X Vu Tung T Zhang Dekai D Pang Da D
Oncotarget 20170201 6
Homeobox A11 (HOXA11) is one of the hypermethylated genes in breast cancer and its function in breast tumorigenesis remains elusive. In this study, we analyzed the methylation status of HOXA11 in 264 paired breast cancer and normal tissue as well as in matched serum samples by MethyLight assay. Further, the function of HOXA11 in breast tumorigenesis was analyzed by cell proliferation and migration assays. We found that HOXA11 was hypermethylated in cancer tissues (45.08%), especially in invasive ...[more]