Ontology highlight
ABSTRACT:
SUBMITTER: Ran J
PROVIDER: S-EPMC5354776 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Ran Jie J Luo Youguang Y Zhang Yijun Y Yang Yang Y Chen Miao M Liu Min M Li Dengwen D Zhou Jun J
Oncotarget 20170201 6
Phosphorylation of end-binding protein 1 (EB1), a key member of microtubule plus end-tracking proteins (+TIPs), by apoptosis signal-regulating kinase 1 (ASK1) has been demonstrated to promote the stability of astral microtubules during mitosis by stimulating the binding of EB1 to microtubule plus ends. However, the roles of other members of the +TIPs family in ASK1/EB1-mediated regulation of astral microtubules are unknown. Herein, we show that ASK1-mediated phosphorylation of EB1 enhances the l ...[more]