Ontology highlight
ABSTRACT:
SUBMITTER: Kozlova N
PROVIDER: S-EPMC5354778 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Kozlova Nina N Wottawa Marieke M Katschinski Dörthe Magdalena DM Kristiansen Glen G Kietzmann Thomas T
Oncotarget 20170201 6
Clinical studies in breast cancer suggest important associations between intratumoral hypoxia, the upregulation of epidermal growth factor receptor (EGFR or HER1), hypoxia-inducible factor 1α (HIF-1α), and reduced patient survival. However, direct molecular links between EGFR and the hypoxia signaling system are not yet established. Since the oxygen sensor hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is considered to be the main HIF-1α regulator, we hypothesized that PHD2 and EGFR may be ...[more]