Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC5355052 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Li Xia X Yin Xiufeng X Wang Huafeng H Huang Jiansong J Yu Mengxia M Ma Zhixin Z Li Chenying C Zhou Yile Y Yan Xiao X Huang ShuJuan S Jin Jie J
Oncotarget 20170201 8
Acute myeloid leukemia (AML) is a highly heterogeneous disease and internal tandem duplication mutation in FMS-like tyrosine-kinase-3 (FLT3-ITD) has a negative impact on outcome. Finding effective treatment regimens is desperately needed. In this study, we explored the inhibitory effect and mechanism of homoharringtonine (HHT) in combination with ibrutinib on FLT3-ITD mutant AML cells. Consequently, we observed a synergistic inhibitory effect when ibrutinib was combined with HHT to inhibit cell ...[more]