Ontology highlight
ABSTRACT:
SUBMITTER: Ihira K
PROVIDER: S-EPMC5355116 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Ihira Kei K Dong Peixin P Xiong Ying Y Watari Hidemichi H Konno Yosuke Y Hanley Sharon J B SJ Noguchi Masayuki M Hirata Noriyuki N Suizu Futoshi F Yamada Takahiro T Kudo Masataka M Sakuragi Noriaki N
Oncotarget 20170201 8
EZH2 inhibition and reactivation of tumor suppressor microRNAs (miRNAs) represent attractive anti-cancer therapeutic strategies. We found that EZH2-suppressed let 7b and miR-361, two likely tumor suppressors, inhibited endometrial cancer (EC) cell proliferation and invasion, and abrogated cancer stem cell-like properties. In EC cells, EZH2 induced and functioned together with YY1 to epigenetically suppress miR-361, which upregulated Twist, a direct target of miR-361. Treating EC cells with GSK34 ...[more]