Ontology highlight
ABSTRACT:
SUBMITTER: Graziano AC
PROVIDER: S-EPMC5355150 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Graziano Adriana Carol Eleonora AC Cardile Venera V Avola Rosanna R Vicario Nunzio N Parenti Carmela C Salvatorelli Lucia L Magro Gaetano G Parenti Rosalba R
Oncotarget 20170201 8
Wilms' tumor gene 1 (WT1) plays complex roles in tumorigenesis, acting as tumor suppressor gene or an oncogene depending on the cellular context. A high WT1 expression level was described in various types of human bone and soft-tissue sarcomas, including osteosarcoma (OS), but its function in carcinogenesis is not yet well understood. This study investigated WT1 both in human OS tissues and in human OS MG-63 cell line in which WT1 gene is up-regulated. The results demonstrated that WT1 is expres ...[more]